I, John Climaco, certify that:


1. I have reviewed this Amendment No. 1 to the Annual Report on Form 10-K/A for the year ended December 31, 2022 of CNS Pharmaceuticals, Inc.; and


2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;




Date: May 1, 2023 By: /s/ John Climaco
    John Climaco
    Chief Executive Officer and President